strangest way to hold/play that ever i've seen was a busker on Grafton Street, Dublin, couple of years ago. He played an electric guitar with the body up in the air over his right shoulder and the neck running down to his lap. He played with what appeared to me to be a "hammering on" style. Sort of reminded me of a piper. He made marvelous music.
Equally true, but far more serious, is a friend who, as a teacher, plays a lot with and for kids. He plays one of those heavy old banjos. He was in the habit of cradeling it between his legs, with the right leg (inside thigh) holding most of the weight. The weight of the instrument apparently pressed on an artery, slowing the blood flow and allowing a clot to form. end result was 6 weeks in the hospital, an ongoing regimen of blood thinners and clot disolvers, and a grotesquely swollen leg, only now, after nearly six moths, approacjhing normal size. Scary!