As a kid I was taken "up" to London, but parents were londoners. I would think that the local big city will always take "up" in common parlance. If you still use proper maps you probably think "up North", "down South". But where does that leave a journey say from Brummagem to Aberystwyth? Now I work on the railway, London is "up", everywhere else is "down". And stations and everything else have "London" and "country" ends. Except that sometimes there's a track joining two others (like the horizontal stroke on a letter "A") And then no bugger knows which way is up!
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