People who work in certain occupations seem to develop hardened skin (callouses) on their hands and fingers naturally and , if they are also guitar players, have no problem, that I've seen or heard of, in any case.
Others , such as myself, don't do much in the line of "manual work" and accordingly have more sensitive finger ends. I always found, and still do, that Methylated Spirits, rubbed in after every practise or session , worked very well to harden the skin on my fingertips.