Lots.

1) Stay awake for a few days, get four hours sleep and do it again.
2) Used to think nothing of a good run. Now, I have to consider taking a walk.
3) I used to have difficulty with the following: I was getting better lookong every day, and it would bother me. Now, I still get better looking every day, but it doesn't bother me at all.
4) I used to be able to plug targets at a hundred yards, dead center, no scope, no problem. Now I can't see a hundred yards. This helps considerably with #3.
5) I am finding it harder to stay angry with people. Even GUEST.

Bruce M