i've always wondered that myself, mbo. i eventually decided it was about how any form of serious inquiry can change you and rob you of your sleep and peace of mind. "she" could be a friend or girlfriend who lives the unexamined life.

2000 years? is that a christ reference? if i knew of a prominent scientist or troubled artist of that age (like a biblical leonardo da vinci?) i would guess it meant him.

i don't know. i'm just pulling this outta my ass anyway.