I'm a full-on left handed person. I tried to learn guitar once but failed miserably because the 'Play with yourself in a day' book was for a right handed person. I never could get the hang of working both hands together, even though I can rub my tummy and pat my head (or vice versa).

Off topic slightly, but LTS's comment above about a left-handed person trying to learn guitar from a book written for a right-handed person makes me wonder - does anyone know of a guitar tutor book written for left-handed people? If not, maybe there would be a market for one :-)

If I can't do it on a guitar, there's no hope for a uke!

A uke should be easier to learn than guitar, having only 4 strings instead of 6 - shouldn't it?

I also 'graduated' from guitar to uke, and found it relatively easy to play chords, with the uke being tuned in the same intervals as the first 4 strings on a guitar ('my dog has fleas' tuning).

But people do underestimate the skill needed to play a uke well, which is why I admire the often unfairly maligned George Formby. The right-hand technique is IMO more difficult to master than the left hand (of course I'm talking here about a right-handed instrument and player).