No, I don't ever knot it, but then I don't string pearls that much. If I do string them, I use fresh water pearls. Pearls do look nice with knots in between and if the stringing material breaks, the knots keep them all from falling off.I used to have some silk thread, but never used it.One of the things I like about C thru B is it lets the colour of the stones, beads, etc. show up nicely. If you use thread, use a colour as close to the beads colour as possible and it can make a nice enhancement, also.

I don't tie it off at the ends. I use crimp beads with special crimping pliers, then feed the C thru B back through the last few beads at each end. I then put a jeweller's glue on the crimped crimp beads. I will have already have put on the clasp and jump ring in the loops of the C thru B before pulling it taut and putting on the crimp beads, etc. If this isn't clear, let me know. I've never actually explained this in writing or without demonstrating before!*smile*

I'll see if I can make an example up and put a picture of it on line, if you'd like, along with pix of some finished pieces.

Another thing that looks nice between beads are seed beads.

Oh, and I don't like the long needle thingies. The C thru B is stiff enough it works as its own needle, plus I didn't find the needles all that stiff or helpful when I first started out, so just never used them.

Thanks for asking. I am going to have more time, now, to maybe get back into beading and I find I have missed it!