I think the idea that Icke speaks of lizards in any kind of metaphorical sense is erroneous. I've watched the videos too, and he means lizards. Quite literally.

If someone believes that they have seen people literally change into lizards in front of them, I would question their sanity.

"Once you decide humans you don't trust/disagree with/feel threatened or persecuted by are in fact not human, but are demons/lizards/aliens, then you don't have to treat them as humans anymore. Dehumanizing real people, regardless of whether they are powerful or wealthy or evil, is wrong, no matter how appealing. Such beliefs cloud judgement and enable atrocity."

I agree.