In the late 1980s and early 1990s, more than 1000 federally insured institutions went under, the government bailout cost taxpayers about $125 billion.
NY International Herald Tribune (NY Times stable), More Will Fail

The FDIC has 117 banks on their "problem list." Financial Times, August 26, 2008- "Number of Struggling US banks rises by 30%," James Politi.

The loss this time may be larger.