That is a lot of driving. It will still be super hot (95+ farenheit and humid) in September, so a light coloured vehicle with AC is a must.

I drove an Isuzu trooper over a mountain (with high winds) daily. As it was a high profile vehicle you could really feel it lift. You just have to adjust to it. Have they looked at a terrain map for the routes they plan to take. There should be something available that shows how sharp the curves and steep the grades are. One good thing is that in US, the roads tend to be wider so there is more room for error.

I should warn about weather and visibilty... you think you get fog here. And there is regular sheeting rain.

As I don't much about the places being visited I can't offer much more. My big bro used to play and sing at Papa Joes on Bourbon Street in Nawlinz but that was when he was a tweenager. Don't know that he has any of his Nawlinz contacts any more.

Hope they have fun.