I'm going to go with Sinsull on the loss of ancient knowledge. So much that the Egyptians knew was considered witchcraft and heresy in the Dark Ages, especially with regard to medicine and dentistry.I'm also going to vote for Mozart.
Two years ago several tornadoes swept through the Nashville area. One of them downed several 100+ year-old trees at the Hermitage, the home of Andrew Jackson. If you have ever been there, you know how majestic the tree-lined driveway was. No more. Some of those trees had been planted by Jackson himself. While they are being replanted, it's not quite the same. The first time I visited there after the storm, I just stood there and cried. (The Gibson Guitar company took some of the wood and made some very collectible "Old Hickory" guitars.)
On a personal level, I lost my father last week to diabetes complications. He was 68 and had a full life but that doesn't make it any easier. Also, last year, the wife of a dear friend was killed in an auto accident. She was 4 months pregnant with their second child. Kathy was one of the sweetest, most special people on the Earth. I miss her still today, because it seemed like there was so much left for her to accomplish.
But like the Good Book says, to everything there is a season.