I have been taking Zoloft (Sertraline HCl) for depression for a couple of years now, and it has done me a world of good. In fact, I am so happy with the outcome, I have no interest in switching to Hypericum.

I did have some side effects at first, but I found that either they diminished with time or else I learned to cope with them. I don't consider them a problem now.

I only wish I had started sooner, and hadn't wasted so much time on counseling, support groups, and self-help books.