Um, is the D# a note in the melody? Because usually when I see a D# in a song, the chord that goes with it is a B.

There's a cheap and easy way to cope with a B chord, because you usually don't play a B chord for very long. Go to the 4th fret, and put fingers on the 3rd, 4th and 5th strings away from your chin. Pluck a little pattern on those three strings and then move on when the B chord is over.   

No doubt there are nice, rich barre chords for B, but I myself have never mastered barre chords.

Is your song in the key of E? Four sharps? B chords are common in E.   D# can also often be found in songs in Em (one sharp) to add a sexy touch. Here at the Mudcat we were just fooling with a song called 'Roslin Castle" which has that.