I think we ignore our spiritual side at our peril, and I embrace the quest for meaning, but I do balk at the kinds "religiosity" that provide the one answer.
In that vein, I like Tom Russells "Guadalupe".
Stephanie Davis "Wolves" speaks to the place where hard lives intersect with hope and the unknown.
Add another for Iris DeMents "Let The Mystery Be".
Gove Scrivenors "I'll Fly Away" is a rollicking good gospel number with a little Doc Watson help.
"Fifty Niles Of Elbow Room" as sung by Red Clay Ramblers.
"I Betcha Heaven's On A Dirt Road" by Larry Jon Wilson (RIP).

Lot's of good musical memories here. I remember alot of these numbers from growing up in a relifious household.