Bottom line for me is cootie free. More concerned about bedbugs than other creatures. Interestingly enough in this day and age, I think mid to higher end motels and hotels in the USA are at greater risk of bedbugs than are lower end chains - less international travel in terms of clientele. I rarely can afford to take leisure travel, and on business, I tend to opt for very cheap motels such as Motel 6. I inspect the bed, bed linens, and shower when I arrive, don't toss anything on the floor or on the bed other than my body, and once I check in, am in the for the night, so not concerned about security or a meth lab two doors down.

I do try to steer clear of any motel/hotel that advertises hourly rates. - Cootie alert, i.e. "crabs," not detectable with a visual inspection.