Regional devolution was voted out a few years back, and won't come back for another generation. Otherwise we end up in the worst of short-termism, holding European-style referenda ad infinitum until we get the result we want.

What is more relevant from this is that we already have a form of regionalism, in that Scotland and Wales have devolved governments, but England does not. The Machine wants to divide and conquer, as always, by thinking about City-based regions (presumably London for the South-East, Bristol for the West, Birmingham for the Midlands, Cambridge for East Anglia, Manchester for the North West, and Newcastle for the North East), but the obvious answer is for England to have the same devolved powers and all devolution to be at the same level.

What we did in WEU coordinating foreign and defence policy in Europe was to ensure that horizontal communication (and no, I don't mean get-a-room) was continued across the Nations so it could not become a Power Game. The same should happen inside the UK, with an Assembly for each devloved Ministerial area to ensure no unmanageabe disparity of policy arises. At that point, the only Central functions needed become those where the UK as a whole has to have a single external position, in other words Foreign and Defence policy and finance.