On the other hand, the question then might arise about the scale of the epidemic overwhelming the medical resource.

Not likely, since the Flu was airborne transmission & the Plague either airborne(pneumonic) or transmitted by flea bites. Ebola requires direct contact with bodily fluids.


what would happen, say, if the whole of Silicon Valley died?

The world would be considerably better off overall and I wouldn't have to constantly deal with oblivious idiots barking into their cell phones & texting in their vehicles.