In terms of heart health trans fats are now seen as a worse culprit than saturated fats even though the role of all dietary fats in heart disease is in some dispute. The big bogeyman man du jour is sugars, fructose in particular. The fact that fully 50% of heart attack victims have what is considered normal (but is really average) cholesterol levels has always been the fly in the ointment as far as the cholesterol/heart disease connection.