Cannabis: funding for research on the subject is understandably difficult to obtain, most is reportage from users & family.

I read in the New Scientist of a report that reckoned the aggression peaked at day 7 after. I saw something akin to this in a colleague. And when I told a friend about this she said "No it is 5 days and 12" though she didn't correlate 7 with the fact that her husband was so difficult she went and got him some more by day 5. 12 - 5 = 7? I am sure of that!

It has long been associated with paranoia, particularly prolonged imbibing, schizophrenia isn't far from that statistically.

Compared to smoking tobacco, it doubles the risk of throat and mouth cancers. Actual percentages may be small but telling none the less.

Yes Yes alcohol is a toxin. But we evolved (in the West) to tolerate it better because alcoholic liquids only fermented properly from potable water. Drinking water without provenance was not always advisable even up to the 1950's in many places.