I have an old Lowden that I mostly use for tune backup in Drop-D and I use a medium string set on it but, as # suggests, I substitute a heavier string on the Low-D (.060) and it takes the flab out nicely so I can hit it pretty hard without a lot of fret rattle and no tuning problems. It hasn't affected my guitar's neck adversely but you might want to check with Lowden beforehand if you go this route.
I also use a DADGAD set (D'Addario EJ24 with a .056 on low-D) on another instrument for playing in that tuning.

I've never played a fan fret but with longer strings on the bass side you will increase string tension on the low side.