Hmmm. I've never had a mouse problem after upgrading to Windows 10, and I've upgraded maybe 20 computers by now. Wish I could say the same for other peripherals.
Is this a wired or wireless mouse, mg? A wireless mouse will probably need a plug-in "dongle" to receive the mouse signal.
If you have that, or if you have a plug-in mouse, go to "support" at the Website of the company that made your mouse. They may have an updated driver.
-Joe-

Here's Microsoft's mouse troubleshooting page:

https://www.microsoft.com/accessories/en-us/support/troubleshooting/mouse/mouse