Jeri, I scoured the journals at a medical school library near my home. One article in Nature (I think) told of researchers who were interviewing patients for an unrelated survey and kept running across very angry, articulate people. It turns out that they were MS patients who had been lied to. This attitude was much more prevalent 50 years ago than it is now.

As far as diagnosis, it's a bit easier now for ~95% of cases because of MRI. I'm always amazed at patients who don't want to do this, or especially who don't want to use one of the ABC drugs because of injections.