One more thought - have you checked for adult onset allergies? Seems to hit early to mid-forties. If it's allergies plus asthma they could be reinforcing each other and fixing one might not give enough relief.

Just knowing what to be cautious of helps. I can pet a cat or dog now - and as long as I wash the dander off the hands reasonably soon - have practically no problems. I had no idea I had any problem til I went with a friend to help clean out her horse's stall and had trouble breathing after.

Elaine