I take NoDoz, I bring tapes and sing along a lot--there's no better way to oxygenate your brain. I DONT play any Bach music. I allow lots of time and take lots of breaks (or a mini-nap).   I try for scenic routes if I can find them. If AAA tells me a trip takes 4 hours, I allow 6+.

I hope my son learns to drive this summer, so we can trade off and actually get somewhere in a reasonable amount of time!