PP...It depends on the guitar, but generally speaking I wouldn't traumatize your Fender with heavies at standard pitch, though tuned down to C# or D would likely be okay. Do the set-up anyway because the nut, truss rod, and saddle may need tweaking. My first attempts at baritone(ish) guitar was by stringing mediums and heavies on an old Tak dread...worked great, but it was no match for my custom baritone. You can always capo up for standard tuning, and the partial capo/virtual tuning potential is fun.

Peace, Mooh.