Yes, I believe it does make a difference. My husband plays 6 and 12 string guitar. I play bass guitar. When we look for a guitar for my husband, it is nothing for me to wait all day for him to find one that fits. The last time he walked into a music store, he made a comment of not liking the looks of a brite red strat....he played every guitar in the house and could not find one he liked. He finally asked me to get him the red strat....after 3 strums, he said, this is the one...it fits....had i known, i would have made him play that one first rather than wait hours for him to play every guitar in the store.

I have found there are some guitars that practically play themselves where others are uncomfortable to the hand and are not a joy to play. Once you find a guitar that fits both your music style of playing as well as your hands, hang on to it because you may never find one like that again.

Good Luck,

Little Doe