Well, Greg, I think you take it too far. We all have our prejudices and ignorances, even in this enlightened age. Every age has its cruelties. If we all lived in the Southerrn United States in the 19th Century, chance are that the vast majority of us would have consider black people inferior, or even inhuman. We may have even made innocent remarks that this enlightened age would think to be horribly prejudiced. If we did not actively participate in the cruelty of our age, I think we could be considered to be good people.

The people you list fit into their era, but they were cruel people of their own accord.

Here's an interesting entry from Fr. Richard McBrien's Harper-Collins Encyclopedia of Catholicism:

Isabella of Castile, 1451—1504, queen of Spain from 1474 who, with her husband Ferdinand of Aragon, created a unified Catholic Spain. The last Muslim state fell in 1492. In that same year all Jews were required to convert or emigrate. The Muslims were placed under the same requirement in 1502. Isabella was deeply religious and drove the reform of the Spanish Church under Ximénez de Cisneros, employing the Spanish Inquisition as an important weapon for political and religious unity. Isabella commissioned Columbus and was committed to the conquest and evangelization of the New World.
Her zeal and accompanying intolerance have made attempts at canonization in the 1990s controversial.

The Office of the Holy Inquisition was the doctrinal tribunal of the Roman Catholic Church, and was in existence from the 12th century or earlier until the mid-20th century. The Spanish Inquisition was a separate entity, inaugurated under Ferdinand and Isabella. There were times that the Roman Inquisition used torture and other cruel methods, but not to the extent used by the Spanish Inquisition. As far as I can tell, only religious penalties were levied after the end of the 16th century. I gather that for most of its history, it was just a church court.
Oh, I'd also like to note that the Pope at the time of Ferdinand and Isabella was Alexander VI, probably the most notorious pope who ever lived. He was the father of Lucretia Borgia.
I don't think McBrien would recommend Isabella for sainthood.
Neither would I, but I don't think I'd get concerned until she is seriously considered for sainthood - and that hasn't happened.
-Joe Offer-