I haven't spent long stretches at a time on the road, but I do a lot of short tours. Here are some of the things I have learned:

Make sure you have accurate maps and directions for everywhere you are going. If I'm gone for more than two days, I make myself a TOUR BOOK. This has one page for every day and includes all the important information for that day:

-where the gig is (address, contact names and phone numbers*)
-where I am staying that night (address, contact names, and phone numbers*)
-when I have to be at the gig and how long the drive will be
-directions to everywhere I have to be
-information on sound check, whether food is supplied by the presenter, and other useful details about that gig

*including cell and/or emergency #s

I put the tour book in a binder. On the first page, I create a summary list with the highlights - date, gig, city, state, contact name and number. I leave a copy of this at home with my partner so she knows where I'm going to be every day.

The tour book has made my life way easier because all the info is in one place and easy to find.

Some other things that are helpful:

I often bring a copy of "The Tofu Toolbooth" with me. This is Dar William's book that lists health food stores and vegetarian cafes all over the US. It's kind of out of date now, but I've still found some nice places to get healthy food with it. Unfortunately, I think the book is out of print now :-(

I contact all the presenters ahead of time, tell them my basic travel plans and make sure they have my cellphone number in case they need to contact me.

I bring healthy things to snack on in the car. Almonds are great for a protein hit. So are pumpkin seeds. Sometimes instead of eating lunch at a restaurant I will go to a grocery store and get some carrots, hummous, cheese and crackers. fruit is also good to have on hand.

If I was more organized, I would keep a cooler in the car with things like hard-boiled eggs, hummous, cheese etc. so that I could avoid eating at restaurants altogether, at least for lunch. But I haven't gotten my act together on that yet.

Make sure you have a way of hiding your instruments in the car - you will be parking your car all over the place and it's better if people don't get the idea there are valuable things inside. I usually carry a blanket with me.

Those are some thoughts off the top of my head. I hope they are helpful tips!