Don, there is a growing body of evidence for the efficacy of psilocybin in the treatment of depression, it is said to reboot or reset the depressed brain. I have a good friend who was in the divine mushroom cultivation business but that too was many years ago. It has been a good while since I have indulged in psychedelics but I recently find myself thinking that I wouldn't mind taking the occasional trip again - that might have something to do with the knowledge that I am closer to the end of my long strange trip than the beginning.