Are you going to dedicate a guitar to this tuning?
If so, then you can choose a tuning and suitable strings - CEGCEG, for example, is not likely to sit well with a standard set of strings, but might be good with the right set.
If not, you probably need to choose a tuning with least deviation from standard - CGCGCE is probably workable.
I think CGCGCD (which has similarities to DADGAD in not being specifically major or minor) has its adherents as well.
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sj