If England is left by itself I think the North/South issues, unless sorted out in the meantime, will become much more polarised. With a smaller population and without the 'distractions' of Wales, NI and Scotland, it would be much more difficult for the London and Home Counties focus to be maintained. I would hope it would reduce the influence of the Eton Mafia. Also, with that amount of constitutional change, surely the role/relevance of the monarchy would be at least called into question.