Twenty and more years ago at Winfield I once sat open-mouthed and watched our friend Art Thieme play "Freight Train" after turning his guitar upside down so as to play it both backwards and left-handed. ('Fess up Art. I know you can do it.)
Given that, I would say about anything is possible.
Also -- and I wish I could recall the band's name -- I saw a group six or seven years ago at a Festival in Sedalia, Mo. I think they were from Alabama. At least it was somewhere in the deep Southeast.
The banjoist -- a VERY capable Scruggs-style player -- had only one or two fingers on his left (fretting) hand due to a birth defect. Naturally he barred a lot of stuff and played almost everything in G, but he made up for it with extrememly deft and complicated rolls.
He also told the following story:
"We played a date in Mississippi a while back, and a little girl there ran home and told her mama, 'MA! MA! I saw these fellows a-pickin', and the banjo was crippled!'"