If you have to have your hands in nasty stuff a lot, I recommend cotton-lined rubber gloves. I get the large size so that there's plenty of air space between the glove and my hand -- it takes a bit of getting used to because they are thicker than the latex ones, but you can flop them off rather than peel them off, which is wonderful. I search out the Bluettes brand, and a pair will last a year or two if I stay away from sharp objects. I rotate them down from kitchen use, to bathroom, and finally to messy d-i-y jobs before they die.