Saccharine has been in use commonly for not quite a century. Back when they decided to test it and were cramming lab rats full of it, they were making them sick. That was amounts like 1000x what you would take in a day, and that much of anything will make you sick. I read a study a few years ago that said when large study groups are reviewed (and there are many human studies now) and under normal usage, saccharine shows absolutely no increased risk of cancer or other illnesses. But you have to understand that what they did to those lab rats to set off the alarms was so bizarre that it skewed the results and people panicked.

SRS