Quite a few printers have a "booklet" option built into their drivers. I have HP Laser and Inkjets, and had an Epson inkjet with this "feature."

As mentioned earlier though, getting through complete passes of both sides of the sheets without a misfeed can be "iffy;" and figuring out how to synch the sheets with the re-start can be a puzzle.

Nearly all printers can be set to print "odd pages" or "even pages," and to "reverse page order," once you figure out how you want to do it. I find it easier to select these myself than to try to rely on the "built-in" printer driver features.

If your default printer has these features, Word will offer some options under page layout that won't be there if you use a "dumb" printer, so your options there may depend on your installation as much as on the layout software you use.

Figuring out the page order to do it all by hand is pretty simple if you do a "mockup," number the pages with everything clipped together, and then use each sheet to make a "printing layout." Ability to print, or reprint, individual sheets is one advantage of "doing it this hard way."

Unless you have, or can improvise, some pretty heavy-duty binding equipment, getting more than about 10 sheets (40 pages) to fold cleanly into a single folio is pretty tough. Even if you fold individual sheets and crease firmly, when you insert them together the "inner" page edges are going to stick out and make page turns difficult. This effect is often worse if individual sheets are crimped tightly before assembly than if you can press the whole stack together, since assembling before you "set" the crease allows the outer sheets to form a larger (closer and tighter) radius around the inner ones in the crease.

John