It's always tricky, because you don't want to escalate a fight (it happens!).

If the rest of the audience is with you, I like "It's a night out for him, but a night off for his family"

I once saw a beleaguered Nigel Mazlin-Jones start on a very long and amusing family story about his father and a donkey that died, the long and short of it being that one day it would come back to haunt him - "I think it's here tonight!"
Uproar from the audience, and a bemused heckler who didn't even realise he'd been insulted.