Well, yes perfect tuning does sound better, unless you wander into a different key. Equal temperament is a compromise, only necessary if you want to modulate to other keys.

Perfect tuning gives perfect harmonies, equal temperament doesn't

For example, a perfect 5th should be a ratio of 3:2, or 1.5, but equal temperament it turns out to be 1.495-ish. This can give rise to 'beat notes' (like the ones a guitarist listens and eliminates to when tuning)