I feed mine into AER 60w backline and there's no problem with clashing of actual and virtual tuning (it doesn't need to be loud (depends on your playing style)) and of course the audience doesn't here the actual strings. What with all the other "noise" on stage plus the wedge foldbacks for vocal/mix it soon gets lost.
It is something to get use to though in quieter settings - but I think well worth it for the ease of dropping in and out of alternate tunings... also it tends to be more noticeable if you capo up the neck.