Been thinking of musicians that I've heard with physical incapacities.
There is a big difference between an accomplished musician who refuses to let a new problem stop him/her, and a beginner with a problem to overcome.
Both are, of course, to be admired, but the musician knows how far they have to go, and also how much they have lost, and can better judge the acceptability of what they can now do.

Years ago, in Coventry, Rod Felton was the rhythm section for a very popular duo. He used various drums, a swanee wistle, and a couple of 'instruments' based around kazoos with tin sounding chambers. Several other whistles and devices were clamped in a rack in front of his chest. He had to be heard to be believed. Wonderful stuff.
Rod hadn't any physical problems, but what he did wouldn't be out of reach for someone with arthritis and determination and a friend who could tailor devices and racks to suit.
The assembly would be awkward to transport and set up, though. Big gigs/groups only.
How about a compromise? Art Thieme's kazoo and Rod's tin kazoo resonating chambers.