I've always been reluctant to try open tunings, except for Drop D, because of the nuisance of retuning for just one song. Drop D is easy, without retuning, by capoing only the first five strings (Thank you Shubb) at the second fret.Since injuring my finger, though, I have tuned my guitars to Open D (DADF#AD) and kept them there. I've got one song, "Payday" almost done, and I'm looking at a few other songs, in Open D. By the time my finger heals all the way (It's doing fine.), I'll have a few songs in Open D, and I'll keep one guitar in that tuning all the time and the other in standard tuning. I like Open D. It's easy to play in and it has a great, ringing sound.
Then there's Open G... Maybe I should buy another guitar... Uh Oh! I feel a GAS attack coming on!