A United Nations Special Commission (UNSCOM) on weapons was established, to monitor Iraq's compliance with restrictions on weapons of mass destruction and ballistic missiles. Iraq accepted some and refused other weapons inspections. The team found some evidence of biological weapons programs at one site and non-compliance at many other sites.

In 1997, Iraq expelled all U.S. members of the inspection team, alleging that the United States was using the inspections as a front for espionage; members of UNSCOM were in regular contact with various intelligence agencies to provide information on weapons sites back and forth. The team returned for an even more turbulent time period between 1997 and 1999; one member of the weapons inspection team, U.S. Marine Scott Ritter, resigned in 1998, alleging that the Clinton administration was blocking investigations because they did not want a full-scale confrontation with Iraq. In 1999, the team was replaced by UNMOVIC, which began inspections in 2002. In 2002, Iraq — and especially Saddam Hussein — became targets in the United States' War on Terrorism, leading to the 2003 invasion of Iraq, led by the United States and, to a lesser extent, the United Kingdom.