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"German Foreign Minister Frank-Walter Steinmeier questioned whether European-led negotiations had any future and said Iran had "crossed lines which it knew would not remain without consequences." He said he had asked ElBaradei to quickly evaluate the dangers of Iran's move.

Britain warned the international community was "running out of patience," and Foreign Secretary Jack Straw said Tehran had breached IAEA resolutions. "There was no good reason why Iran should have taken this step if its intentions are truly peaceful," Straw said.

Japan said the decision was "a matter of deep regret" and the Foreign Ministry called on Iran "to immediately cease the resumption of the research and development activities."

Iran's decision to freeze some nuclear activities in October 2003 was voluntary, so the IAEA said it had no option but to remove the seals at Iran's request.

The move further erodes the suspension of nuclear activities that has been the centerpiece of Iran's negotiations with the West since the freeze was put in place as a confidence-building measure.

In August, Iran removed seals at another nuclear plant outside the city of Isfahan and resumed uranium reprocessing — a step before enrichment in the nuclear fuel process.

That move prompted Europe to break off its negotiations temporarily. The talks that resumed in December made no progress but were to continue later this month.

French    President Jacques Chirac on Tuesday warned Iran it would commit a serious mistake if it ignored the international community."