IMO, when Israel sees it has nothing to lose, there will be a nuclear strike against all their enemies in the mid-East.

This is nuclear blackmail, Peace. Israel will never have "nothing to lose". If Israel would decide to do what you have described, the suffering of the Israelis will be far greater than that of Israel's neighbors. Because the Israelis will die much, much more slowly from the after-effects of it's bombs than the people it targets. Only stupid people would do something like that. I don't think Israelis are stupid.