I can think of one other affliction- an amputee, Peg Leg Howell (?) although I've never heard any of his songs. Plus there's a guy out of Chicago - Left Hand Frank. I don't know if that qualifies as an affliction, though. By the sound of it, he plays his guitar upside down like Hendrix did.

With all the new classes of disorders and victimization, I'm sure we'll soon be hearing blues from such folks as Attention-deficit Papaya Bush and Differently-abled Mango Nixon (not to mention Dyslexic Coconut Carter).