The trick with tuning between songs if you have a lot of different tunings is to plan it out so's that you can easily get from one tuning to another to another to another etc, rather than jumping haphazardly from unrelated tuning to unrelated tuning - as well as the aforementioned stuff about talking over tuning bouts. Of course, this makes a live set a lot more inflexible and less spontaneous than if you were just using one tuning and could choose songs more at will and on the spot... but it's a satisfying challenge to work within those kinds of limitations.