I am also an insulin dependant diabetic and have been for years. My thyroid is also underactive, so underactive that my doctor told me it may as well be dead. Here's the thing, and you may well already know this, but when you are diabetic, your entire endocrine/hormone system can be messed up, it just kind of goes with the territory. The BEST advice I can give you is to really stay on top of those sugar levels and take the Synthroid (or whatever you will be taking) like you are supposed to. There have been occassions when I haven't taken mine for a long time (I know, I know...) and ended up a disaster area. From your name, I can't tell if you are a man or a woman, but if you are a woman you should know that polycystic ovary syndrome travels in this same bunch of health issues and can be a huge problem as well. If you keep the thyroid levels where they should be, this can reduce the symptoms in a HUGE way...weird how it's all connected, but it is. You should also be aware (and hopefully your doctor has told you) that thyroid medication is photosensitive....hot summer days in the sun will make you sick to your stomach and your skin will be MUCH MORE likely to get sunburned, seriously, be careful with the sun. I learned the hard way. Sunblock and shade are your friends. The thyroid medication is just a small pill taken once a day. You should start feeling results (less tired and draggy) in a few weeks. Initially, you will probably need a blood test every 2 months or so until they get the right dosage level for your body. I don't know anything about lupus but I think you are on the right track in talking to others who share the same conditions.