I highly recommend an ABY signal splitter to anyone who likes to fool around with effects and has access to two amplifiers. The ABY lets you send the same signal to two amps, one with clean settings and one with all the effects. Put one on each side of the room and it's like you're playing two guitars at once.

I use a Fender Acoustasonic for the acoustic side and a Marshall adjusted for lots of crunchiness for the effects side. Any pedals go in the line from the splitter to the Marshall so that it only effects the sound coming from that amp, not the Fender.

It's not something I do frequently because I don't have room to keep a bunch of equipment set up all the time, but it's fun when I get bored enough to pull the backpack full of cords and pedals out.