Correction:

The line "We can but try. Sherlock Holmes." is probably a signature quote used by that poster and not part of the parody.

With that deletion, the entire song would be:

HIT THE ROAD, JOE
Hit the road, Joe
And don't ya come back no more no more
Hit the road, Joe
And don't ya come back no more.
You Republican whore.

What you say??

Joe oh Joe you treat us so mean
(you're the worst Democratic Senator we've ever seen
and if you keep treating us so
we'll have to take our votes and go

That's right!

What I say

Hit the road, Joe
Woah, Senator, oh Senator, don't treat my party so mean
You're the meanest old Senator that I've ever seen
I guess if we said so
You have to pack your things and go (That's right)

[chorus]

Now Joe, listen, Joe, don't ya treat me this-a way
Cause the Democratic Party be back on its feet some day
(Don't care if you are 'cause it's understood)
(You took Repubilcan money you just ain't no good)
Well, I guess if we say so
You have to pack your things and go (That's right)

[repeat chorus]

----

"Joe" of course, is Senator Joe Lieberman. And the political campaign is the August 8, 2006 Democratic primary in Connecticut between Leiberman and Ned Lamont.