As Stigweard says, you get lots of beautiful drones and suspended chord sounds, especially when playing in the keys of D and G, that are just so right for folk music with the top courses tuned to D and that will be missed entirely by using GDAE. I would suggest if you want the more resonant sound of a bouzouki but the ease of playing tunes, then an octave mandola would be a better choice. The recent workshop I attended, we mixed tunes and accompaniment without any problem. The stretch or having to think about that D course could be a problem, but it's like all things, once you get used to it, you stop thinking and just do it.