Pogo was, well, the best. But there have been many recent comics out there, too:

Calvin and Hobbes
Bloom County
Boondocks
Sherman's Lagoon
Sally Forth
and others.

In the old category:

L'il Abner
Krazy Kat
Asterix
Tintin
Buck Rogers
and others, including the Yellow Kid.

But because taste is so subjective, I don't think that anyone can say that "THIS is the best of the best!"